Anticancer activities of constituents from the stem of Polyalthia rumphii.

نویسندگان

  • Tianshan Wang
  • Yuan Yuan
  • Jing Wang
  • Changri Han
  • Guangying Chen
چکیده

Nine known compounds were firstly isolated from the chloroform extract of Polyalthia rumphii stem by anticancer activity guidance, and the chemical structures were identified by using spectroscopic and physico-chemical analysis. Cytotoxic evaluation against four cancer cell lines was performed on all these compounds, which showed that K562 could be significantly inhibited by partial compounds with IC(50) values at the range from 40 to 60 μ/mL.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Bioactive 4-hydroxycinnamide and bioactivities of Polyalthia cerasoides

Constituents from Polyalthia cerasoides, stem bark methanol extract, were previously documented. This study reports the first isolation of bioactive N-(4-hydroxy-β-phenethyl)-4-hydroxycinnamide (1) from ethyl acetate extract of the plant species including stigmasterol and a mixture of triterpenes from hexane and dichloromethane extracts. Trace essential elements were found in the hexane extract...

متن کامل

Synthesis and Biological Evaluation of Novel Mono Acid Esters Derived from the Constituents of Urtica pilulifera

Abstract: New mono acid esters have been synthesized from the reaction of benzoic acid and mono-hydroxybenzoic acids with 2-phenoxyethanol separated from Urtica pilulifera, characterized, and screened for possible antioxidant, antifungal, antimicrobial and anticancer activities. These phenolic acid esters gave various degrees of free radical scavenging, but the values were lower than that of α-...

متن کامل

Synthesis and Biological Evaluation of Novel Mono Acid Esters Derived from the Constituents of Urtica pilulifera

Abstract: New mono acid esters have been synthesized from the reaction of benzoic acid and mono-hydroxybenzoic acids with 2-phenoxyethanol separated from Urtica pilulifera, characterized, and screened for possible antioxidant, antifungal, antimicrobial and anticancer activities. These phenolic acid esters gave various degrees of free radical scavenging, but the values were lower than that of α-...

متن کامل

High Performance Thin Layer Chromatography and High Performance Liquid Chromatography determination of Quercetin from Polyalthia longifolia leaves

Introduction: Polyalthia longifolia Thwaites (PL) is an ornamentally important flowering tree with immense potential. Identification of phytochemical constituents from plant extracts is need of hour in developing countries like India. These elucidated constituents may play a pivotal role in providing remedies to plethora of diseases whether major or minor. Proper application of analytical techn...

متن کامل

Bioactive azafluorenone alkaloids from Polyalthia debilis (Pierre) Finet & Gagnep.

This study investigated bioactive extracts of Polyalthia debilis (Annonaceae) with antimicrobial, antimalarial and cytotoxic activities. Extensive chromatographic isolations provided azafluorenone alkaloids; onychine (1) and 7-methoxyonychine (2) together with a mixture of beta-sitosterol and stigmasterol. The two alkaloids were isolated from the P. debilis for the first time. Isolated fraction...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Pakistan journal of pharmaceutical sciences

دوره 25 2  شماره 

صفحات  -

تاریخ انتشار 2012